Differential effects of CSF-1R D802V and KIT D816V homologous mutations on receptor tertiary structure and allosteric communication.
The colony stimulating factor-1 receptor (CSF-1R) and NFL Packs the stem cell factor receptor KIT, type III receptor tyrosine kinases (RTKs), are important mediators of signal transduction.The normal functions of these receptors can be compromised by gain-of-function mutations associated with different physiopatological impacts.Whereas KIT D816V/H